Scale Bio Revolutionizes Single-Cell Research with QuantumScale RNA Kits Now Available Globally
Scale Biosciences, Inc. (Scale Bio), a pioneer in scalable single-cell technologies, has announced the commercial availability of its groundbreaking QuantumScale Single Cell RNA Kits, empowering researchers worldwide to analyze millions of cells in a single workflow. This milestone comes as Scale Bio joins forces with the Chan Zuckerberg Initiative’s (CZI) Billion Cells Project, a landmark initiative aimed at generating an unprecedented one-billion-cell dataset to accelerate advancements in cell biology and AI-driven discoveries.
Scaling the Future of Single-Cell Research
The Billion Cells Project represents a monumental effort to push the boundaries of single-cell omics by creating the largest and most diverse cellular dataset ever assembled. Scale Bio is collaborating alongside industry leaders like 10x Genomics and Ultima Genomics to expand data generation capabilities for this transformative project. By integrating its proprietary QuantumScale and ScalePlex technologies, Scale Bio is enabling researchers to conduct experiments at a scale previously deemed infeasible, cumbersome, or cost-prohibitive.
Scale Bio’s participation builds on its successful “100 Million Cell Challenge,” supported by CZI, Ultima Genomics, NVIDIA, and BioTuring. This earlier initiative laid critical groundwork for large-scale single-cell studies and demonstrated the potential of QuantumScale technology to handle massive datasets efficiently. The integration of Scale Bio’s tools into the Billion Cells Project will further accelerate the generation of high-quality, diverse cellular data, fueling breakthroughs in biological understanding and AI model development.
“At Scale Bio, we are committed to accelerating scientific progress through the power of scale to improve human health,” said Giovanna Prout, President and CEO at Scale Bio. “For too long, technological limitations have constrained what’s possible in single-cell research. With our QuantumScale and ScalePlex technologies, we’ve reimagined single-cell analysis to drive unprecedented scalability. We’re proud to collaborate with CZI and participating researchers on the Billion Cells Project, helping generate data across diverse biological models at the scale needed to power new discoveries and develop impactful AI models.”
Transformative Technology for Unprecedented Scale
Scale Bio’s QuantumScale Single Cell RNA Kits are now available in five configurations for academic and commercial customers globally. These kits represent a dramatic leap forward in single-cell analysis, offering unmatched scalability and efficiency:
- Up to 4 Million Cells per Workflow: QuantumScale can capture and process up to 4 million cells in a single, streamlined workflow without requiring specialized partitioning instrumentation.
- Sample Multiplexing with ScalePlex: Researchers can multiplex up to 9,216 samples or conditions per run, making it uniquely suited for large-scale projects like the Billion Cells Project.
This scalability is a game-changer for researchers tackling complex biological questions. For example, Kevin Matthew Byrd, DDS, PhD, a researcher at Virginia Commonwealth University and recipient of a 100 Million Cell Challenge grant, is leveraging QuantumScale to map millions of cells across the inhalation interface—from the oral cavity through the upper airway and into the lung.
“Chronic conditions like sarcoidosis and Sjögren’s disease impact the entire cul-de-sac of breathing,” said Dr. Byrd. “Scale Bio’s QuantumScale technology allows us to map millions of cells across these connected niches, uncovering shared mechanisms and opening the door to new diagnostic and therapeutic insights.”
Accelerating AI Model Development
Large-scale single-cell analysis initiatives like the Billion Cells Project are essential for building a comprehensive understanding of cellular diversity and behavior. These efforts not only deepen our knowledge of gene function and cellular interactions but also provide the foundational data needed to train advanced AI models. Once completed, the billion-cell dataset will offer unparalleled resolution across multiple domains of biology, driving transformative discoveries in precision medicine, functional genomics, and beyond.
“Scale Bio will be a valuable partner in achieving our grand scientific challenge of building an AI-based virtual cell model to predict and understand cellular behavior,” said Jonah Cool, PhD, Senior Science Program Officer for Cell Science at CZI. “This collaboration will allow researchers to answer specific biological questions about cells and derive high-quality data with unprecedented scale and accessibility. We hope this partnership with Scale Bio is just the beginning of how innovative technologies can remove barriers to data generation, enabling researchers to build more comprehensive AI models that could provide insights into health and disease.”
Why Scale Bio’s Technology Matters
The ability to analyze millions of cells efficiently is critical for addressing some of the most pressing challenges in biology and medicine. Traditional single-cell analysis methods often struggle with scalability, cost, and complexity, limiting their applicability to large-scale projects. Scale Bio’s QuantumScale technology overcomes these barriers, offering researchers:
- Unmatched Scalability: Analyze millions of cells in a single workflow, unlocking new possibilities for large-scale studies.
- Cost Efficiency: Reduce costs associated with traditional single-cell analysis while maintaining high data quality.
- Versatility: Support diverse applications, from mapping cellular landscapes to identifying novel biomarkers and therapeutic targets.
By democratizing access to scalable single-cell analysis, Scale Bio is empowering researchers to tackle ambitious projects that were once out of reach.
A New Era of Discovery
The convergence of Scale Bio’s cutting-edge technology with the CZI Billion Cells Project marks a turning point in single-cell research. As researchers gain access to vast, high-quality datasets, they will be better equipped to train AI models that reflect the complexity of human biology. These advancements hold the potential to revolutionize fields like precision medicine, drug discovery, and regenerative therapies.
With its QuantumScale Single Cell RNA Kits now commercially available, Scale Bio is poised to become an indispensable partner for academic and commercial researchers worldwide. By breaking down technological barriers and enabling unprecedented scalability, Scale Bio is paving the way for transformative discoveries that will shape the future of science and medicine.
To learn more about Scale Bio’s QuantumScale technology and how it can accelerate your research, visit Scale Bio’s website.
